Gluten

As part of your specialist consultation at the Children’s Clinic | Allergy Centre, 
you will be investigated for coeliac disease/ gluten sensitivity/ gluten intolerance, if indicated.

Suggestive symptoms are given on the “Big List”.  

To make the diagnosis of gluten sensitivity / or coeliac disease, we will arrange your blood tests (skin tests do not help).
Medical studies show that gluten can affect people in many sorts of ways.
Over 300 symptoms and diseases have been associated with gluten illness.
Blood tests help make the diagnosis.

Gluten Sensitivity blood tests

Evidence of non-coeliac gluten illness can be tested by the detection of gluten/gliadin antibodies:

  •  Anti gliadin antibody – IgG
  •  Anti gliadin antibody – IgA

A positive test tells you that you have an immune reaction to gluten. 
Most gluten-sensitive people will have a high IgG-gliadin test.
However, it is not a definitive test.
The only certain way to determine gluten sensitivity is to try out a gluten-free diet.  

 The IgG-gliadin test is a gluten test.  It does not detect coeliac disease.

Discussion about the IgG-gliadin test

Currently, there is controversy surrounding the interpretation of these  gliadin antibody tests.
High levels are found in about 10% of the population.

The brief history of the IgG-gliadin tests:
In the 1990s, the anti-gliadin IgG antibody test (often referred to as the IgG-gliadin test) was used to verify suspicion of coeliac disease. But in the 2000s, the gluten test was shown to be  a poor predictor of coeliac disease.  Consequently, gastroenterologists (mistakenly) have concluded that these gluten blood tests are inaccurate and irrelevant. Their viewpoint comes from their focus on gut damage. 

Other research shows that the IgG-gliadin antibody test is valuable for detecting people who are reacting adversely to gluten (but who do not have coeliac disease).  This includes neurological disease. (see: Gluten sensitivity: from gut to brain. http://www.thelancet.com/journals/laneur/article/PIIS1474-4422(09)70290-X/abstract)

Gluten Sensitivity and the Impact on the Brain: http://www.huffingtonpost.com/dr-david-perlmutter-md/gluten-impacts-the-brain_b_785901.html

The association between symptoms and high levels of gluten antibodies has been widely investigated.  Dr Ford’s research shows that high levels of gluten antibodies accurately predict a beneficial response to a gluten-free diet (http://www.medical-hypotheses.com/article/S0306-9877(09)00223-0/abstract).

High IgG-gliadin antibody levels are indicative of an immunological reaction to gluten, which can manifest as significant poor health – The Gluten Syndrome.

You can read more about this in Dr Ford’s book “The Gluten Syndrome: Is wheat making you sick?” 

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